Non-human primates (NHPs) are an extremely important animal model for malaria vaccine development. In this study, purified, vialed, cryopreserved Plasmodium knowlesi sporozoites (PkSPZ) were produced by Sanaria, Inc. and tested in studies by Sanaria, NIH, and UW to show that the PkSPZ product resulted in reliable, reproducible infections in two macaque species. Because PkSPZ are cryopreserved, the PkSPZ approach provides more experimental flexibility in planning and scheduling than when infected mosquitoes are used to inoculate the parasite. This NHP/PkSPZ model provides a rigorous experimental system that can be used to study anti-malarial immune responses including those that are inaccessible in humans. The study was led by Dr. Sumana Chakravarty at Sanaria. UW Acting Instructor Dr. Melanie Shears led the UW's pigtailed macaque NHP research in this study with support from the Washington National Primate Research Center P51 award (link).
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