Manuscript is available at:
https://malariajournal.biomedcentral.com/articles/10.1186/s12936-020-03385-4
Our team, led by Melanie Shears, PhD (Acting Instructor, Laboratory Medicine and Pathology) recently published a comparative study of P. falciparum vs. P. knowlesi infection of rhesus macaques as part of our NHP malaria model development efforts. Although it was long known that P. falciparum cannot infect rhesus erythrocytes, the literature and our data led us to hypothesize that infection might still be occurring in the preceding liver-stage. However, this study showed that P. falciparum sporozoites do not lead to the prolific liver stage growth seen for P. knowlesi, an NHP-adapted Plasmodium species. This finding means that we will rely on P. knowlesi in the rhesus NHP model for all pre-erythrocytic and erythrocytic malaria vaccine development or look to P. falciparum controlled human malaria infection during evaluations of vaccine efficacy. Thanks to Sanaria for their collaboration on this project and in ongoing NHP studies.
Manuscript is available at: https://malariajournal.biomedcentral.com/articles/10.1186/s12936-020-03385-4 |
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