needle-free spirulina-based P. falciparum CSP malaria vaccine study now published in npj vaccines10/4/2022 Our new paper on a Plasmodium falciparum circumsporozoite protein (PfCSP) vaccine composed of PfCSP-bearing VLPs expressed by the edible algae spirulina (scientific name: Arthrospira platensis) is now online in npj Vaccines (LINK). In this Phase 1 STTR-funded study, a combination of intranasal priming and oral boosting achieved high titer anti-PfCSP antibody responses that protected mice against PfCSP-expressing sporozoite challenge up to 140 days post-vaccination. This approach is being further pursued by our team and Lumen Bioscience in a Phase 2 NIH STTR project. If developed, needle-free vaccination approaches have the potential to simplify vaccine administration and improve vaccine uptake.
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