overview of our research
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Check out the University of Washington Laboratory Medicine Grand Rounds talk by Dr. Murphy describing our group's work. Click the video or follow this link. |
SELECTED publications
Searchable at Pubmed (https://www.ncbi.nlm.nih.gov/pubmed)
Molecular Diagnostics & Epidemiology
Pre-clinical Malaria Drug/Vaccine Development
Malaria Parasite Biology & Pathogenesis
Vaccines for Other Pathogens
Ethics and Global Health Policy Papers
Molecular Diagnostics & Epidemiology
- Murphy SC, Prentice JL, Williamson K, Wallis CK, Fang FC, Fried M, Pinzon C, Wang R, Talley AK, Kappe SHI, Duffy PE, Cookson BT. 2012. Real-time quantitative reverse transcription PCR for monitoring of blood-stage Plasmodium falciparum infections in malaria human challenge trials Am J Trop Med Hyg. 86(3):383–94. (https://doi.org/10.4269/ajtmh.2012.10-0658)
- Murphy SC, Daza G, Chang M, Coombs RW. 2012. Laser cutting eliminates nucleic acid cross-contamination in dried blood spot processing. J Clin Microbiol. 50(12):4128-30. (https://doi.org/10.1128/JCM.02549-12)
- Murphy SC, Shott JP, Parikh S, Etter P, Prescott WR, Stewart VA. 2013. Malaria Diagnostics in Clinical Trials. Am J Trop Med Hyg. 89(5):824-839. (https://doi.org/10.4269/ajtmh.12-0675)
- Murphy SC, Hermsen CC, Douglas AD, Edwards NJ, Petersen P, Fahle GA, Adams M, Berry AA, Billman ZP, Gilbert SC, Laurens MC, Leroy O, Lyke KE, Plowe CV, Seilie AM, Strauss KA, Teelen K, Hill AVS, Sauerwein RW. 2014. External quality assurance of malaria nucleic acid testing for clinical trials and eradication surveillance PLoS ONE 9(5): e97398. (https://doi.org/10.1371/journal.pone.0097398)
- Hodgson SH, Douglas AD, Edwards NJ, Kimani D, Elias SC, Chang M, Daza G, Seilie AM, Magiri C, Muia A, Juma EA, Cole AO, Rampling TW, Anagnostou NA, Gilbert SC, Hoffman SL, Draper SJ, Bejon P, Ogutu B, Marsh K, Hill AVS, Murphy SC. 2015. Increased sample volume and use of quantitative reverse-transcription PCR can improve prediction of liver-to-blood inoculum size in controlled human malaria infection studies. Malaria J 14:33. (https://doi.org/10.1186/s12936-015-0541-6) (PMC4318195)
- Fang FC, Billman ZP, Wallis C, Abbott A, Olson J, Dhanireddy S, Murphy SC. 2015. Human Diphyllobothrium nihonkaiense infestation in Washington State. J Clin Microbiol 53(4):1355-7. (https://doi.org/10.1128/JCM.00065-15) (PMCID: PMC4365193)
- Hanron AH, Billman ZP, Seilie AM, Chang M, Murphy SC. 2016. Detection of Babesia microti parasites by highly sensitive 18S rRNA reverse transcription PCR. Diag Microbiol Infect Dis. 87(3):226-8. (https://doi.org/10.1016/j.diagmicrobio.2016.11.021)
- Hanron AE, Billman ZP, Seilie AM, Olsen TM, Fishbaugher M, Chang M, Rueckle T, Andenmatten N, Greenhouse B, Arinaitwe E, Rek J, Das S, Domingo GJ, Shipman K, Kappe SH, Kublin JG, Murphy SC. 2017. Multiplex, DNase-free one-step reverse transcription PCR for Plasmodium 18S rRNA and spliced gametocyte-specific mRNAs. Malaria J 16(1):208. (https://doi.org/10.1186/s12936-017-1863-3) (PMC5438523).
- Das S, Jang IK, Barney B, Peck R, Rek J, Arinaitwe E, Adama H, Murphy M, Imwong M, Ling C, Proux S, Haohankhunnatham W, Rist M, Seilie AM, Hanron A, Daza G, Chang M, Nakamura T, Kalnoky M, Labarre P, Murphy SC, McCarthy J, Nosten F, Greenhouse B, Domingo GJ. 2017. Performance of a high-sensitivity rapid diagnostic test for Plasmodium falciparum malaria in asymptomatic individuals from Uganda and Myanmar and naïve human challenge infections. Am J Trop Med Hyg 97(5):1540-1550 (PMID 28820709) (https://doi.org/10.4269/ajtmh.17-0245)
- Fahle GA, Luethy PM, Murphy SC, Seilie AM, Xie YL, Lau C, Tisdale JF, Hsieh MM, Reinhardt JL, Lau AF. 2018. Case Report: Diagnostic challenges of prolonged post-treatment clearance of Plasmodium nucleic acids in a pre-transplant autosplenectomized patient with sickle cell disease. Malaria J. 17:23 (https://doi.org/10.1186/s12936-017-2152-x)
- Murphy SC, Ishizuka AS, Billman ZP, Olsen TM, Seilie AM, Chang M, Smith N, Chuenchob V, Chakravarty S, Sim BKL, Kappe SHI, Hoffman SL, Seder RA. 2018. Plasmodium 18S rRNA of intravenously administered sporozoites does not persist in peripheral blood. Malaria J 17:275. (https://doi.org/10.1186/s12936-018-2422-2)
- Plucinski MM, Herman C, Jones S, Dimbu R, Fortes F, Ljolje D, Lucchi N, Murphy SC, Smith NT, Cruz KR, Seilie AM, Halsey ES, Udhayakumar V, Aidoo M, Rogier E. 2019. Screening for Pfhrp2/3-Deleted Plasmodium falciparum, Non-falciparum, and Low-Density Malaria Infections by a Multiplex Antigen Assay. J Infect Dis. 219:437-47. (https://doi.org/10.1093/infdis/jiy525)
- Plucinski MM, Dimbu R, Fortes F, Murphy SC, Smith NT, Cruz KR, Seilie AM, Halsey ES, Aidoo M, Rogier E. 2019. Malaria parasite density in individuals with different rapid diagnostic test results and concentrations of HRP2 antigen. Amer J Trop Med Hyg 100(5):1202-3. (https://doi.org/10.4269/ajtmh.19-0006).
- Seilie AM, Chang M, Hanron AE, Billman ZP, Stone BC, Zhou K, Olsen TM, Daza G, Ortega J, Cruz K, Smith NT, Healy SA, Neal J, Wallis CK, Fritzen E, Shelton L, VonGoedert T, Wong-Madden S, Kappe SHI, Fishbaugher M, Betz W, Hume JCC, Talley AK, Wald A, Plowe CV, Adams M, Fahle GA, Cowan E, Duffy PE, Kublin JG, Murphy SC. 2019. Beyond blood smears for malaria - clinical validation of the Plasmodium 18S rRNA as a biomarker for controlled human malaria infections. Amer J Trop Med Hyg 100(6):1466-1476. (https://doi.org/10.4269/ajtmh.19-0094)
- Report on the successful FDA Biomarker Qualification of the Plasmodium 18S rRNA for a non-endemic controlled human malaria infection context of use. First malaria biomarker qualified at the FDA in this manner.
- Jang IK, Tyler A, Lyman C, Kahn M, Kalnoky M, Rek J, Arinaitwe E, Adrama H, Murphy M, Imwong M, Ling C, Proux S, Haohankhunnatham W, Rist M, Seilie A, Hanron A, Daza G, Chang M, Das S, Barney R, Rashid A, Landier J, Boyle D, Murphy S, McCarthy J, Nosten F, Greenhouse B, Domingo G. 2018. Simultaneous Quantification of Plasmodium Antigens and Host Factor CRP in Asymptomatic Individuals with Confirmed Malaria Using a Novel Multiplex Immunoassay. J Clin Microbiol JCM.00948-18 (https://doi.org/10.1128/JCM.00948-18)
- Cunningham JA, Thomson RM, Murphy SC, de la Paz Ade M, Ding XC, Incardona S, Legrand E, Lucchi NW, Menard D, Nsobya SL, Saez AC, Chiodini PL, Shrivastava J. 2020. WHO malaria nucleic acid amplification test external quality assessment scheme: results of distribution programmes one to three. Malaria J. 19(1):129. (https://doi.org/10.1186/s12936-020-03200-0). PMID: 32228615.
- Jimmy OT, Emmanuel O, Gonzaga A, Basil O, Jimmy L, Murphy SC, Egwang TG. 2020. Using the ultrasensitive Alere Pf Malaria Ag HRP-2TM rapid diagnostic test in the field and clinic in northeastern Uganda. Amer J Trop Med Hyg. 103(2):778-784. https://doi.org/10.4269/ajtmh.19-0653. PMID: 32602431
- Vasquez AM, Velez GJ, Medina AC, Serra-Casas E, Campillo A, Gonzalez IJ, Murphy SC, Seilie AM, Tobon-Castano A. Evaluation of highly sensitive diagnostic tools for the detection of P. falciparum in pregnant women attending antenatal care visits in Colombia. BMC Preg Childbirth. 20(1):440. https://doi.org/10.1186/s12884-020-03114-4. PMID: 32736543
- Francis A, Shears M, Murphy SC, Fu D. Direct quantification of single red blood cell hemoglobin concentration with multiphoton microscopy. Analytical Chem. 92(18):12235-12241. https://doi.org/10.1021/acs.analchem.0c01609. PMID: 32786430.
- Glasgow HK, Cruz K, Murphy SC. 2021. Reverse-transcription PCR increases sensitivity of broad-range fungal detection in bronchoalveolar lavage fluid. Med Mycol. myab061, https://doi.org/10.1093/mmy/myab061
- Wang CYT, Ballard E, Pava Z, Marquart L, Gaydon J, Murphy SC, Whiley D, O’Rourke P, McCarthy JS. 2021. Analytical validation of a real-time hydrolysis probe PCR assay for quantifying Plasmodium falciparum parasites in experimentally infected human adults. Malar J 20:181 https://doi.org/10.1186/s12936-021-03717-y. PMID: 33838672
- Hergott DEB, Balkus JE, García GA, Cruz KR, Seilie AM, Masters H, Aveika AA, Iyanga MM; Eyono JNM, Guthrie BL, Murphy SC. 2021. Clustering of subpatent infections in households with asymptomatic rapid diagnostic test-positive cases in Bioko Island, Equatorial Guinea independent of travel to regions of higher malaria endemicity: a cross-sectional study. Malaria J. 20(1):313. doi: 10.1186/s12936-021-03844-6. PMID: 34247643
- Chang M, Johnson S, Seilie AM, Hergott D, Murphy SC. 2021. Application of dried blood spot sample pooling strategies for Plasmodium 18S rRNA biomarker testing to facilitate identification of infected persons in large-scale epidemiological studies. Malar J DOI: 10.1186/s12936-021-03907-8. PMID: 34620192
- Hergott DEB, Owalla TJ, Balkus JE, Apio B, Lema J, Cemeri B, Akileng A, Seilie AM, Chavtur C, Staubus W, Chang M, Egwang TG, Murphy SC. 2022. Feasibility of community at-home dried blood spot collection combined with pooled reverse transcription PCR as a viable and convenient method for malaria epidemiology studies. Malaria J (accepted).
- Matsubara J, Chang M, Seilie AM, Murphy SC. 2022. Flow cytometric sorting of infected erythrocytes demonstrates reliable detection of individual ring-stage Plasmodium falciparum parasites by Plasmodium 18S rRNA reverse transcription PCR. Am J Trop Med Hyg. 11:tpmd211226. (https://doi.org/10.4269/ajtmh.21-1226). PMID: 35405648.
Pre-clinical Malaria Drug/Vaccine Development
- Murphy SC, Kas A, Stone BC, Bevan MJ. 2013. A cytotoxic T cell response to a liver-stage Plasmodium antigen is not boosted by repeated sporozoite immunizations. Proc Natl Acad Sci USA 110(15): 6055–6060. (https://doi.org/10.1073/pnas.1303834110)
- Douglass AN, Kain HS, Abdullahi M, Arang N, Austin LS, Mikolajczak SA, Billman ZP, Hume JC, Murphy SC, Kappe SH, Kaushansky A. 2015. Host-based prophylaxis successfully targets liver stage malaria parasites. Mol Ther. 23(5):857-65. (https://doi.org/10.1038/mt.2015.18) (PMC4427874)
- Stone BC, Kas A, Billman ZP, Murphy SC. 2016. Complex synthetic minigene T cell vaccination for Plasmodium antigen discovery. PLoS One. 11(4):e0153449. (https://doi.org/10.1371/journal.pone.0153449). PMC4829254
- Billman, ZP, Kas A, Stone BC, Murphy SC. 2016. Defining rules of CD8+ T cell expansion against pre-erythrocytic Plasmodium antigens in sporozoite-immunized mice. Malaria J 15(1):238. (https://doi.org/10.1186/s12936-016-1295-5).
- Billman ZP, Seilie AM, Murphy SC. 2016. Purification of Plasmodium sporozoites enhances parasite-specific T cell responses Infect Immun 84(8):2233-42. (https://doi.org/10.1128/IAI.01439-15).
- Sack BK, Mikolajczak SA, Fishbaugher M, Vaughan AM, Flannery EL, Nyugen T, Betz W, Navarro MJ, Foquet L, Steel RWJ, Billman ZP, Murphy SC, Hoffman SL, Chakravarty S, Sim BKL, Behet M, Reuling IJ, Walk J, Scholzen A, Sauerwein RW, Ishizuka AS, Flynn B, Seder RA, Kappe SHI. 2017. Humoral protection against mosquito bite-transmitted Plasmodium falciparum infection in humanized mice. NPJ Vaccines 2 (article 27. (https://doi.org/10.1038/s41541-017-0028-2).
- Flannery EL, Foquet L, Chuenchob V, Fishbaugher M, Billman ZP, Foquet L, Navarro MJ, Betz W, Olsen TO, Lee J, Scafer C, Sack B, Wilson E, Bial J, Campo B, Charman S, Saunders J, Murphy SC, Phillips MA, Kappe SHI, Mikolajczak S. 2018. Assessment of drug efficacy against P. falciparum liver stages in a liver-chimeric humanized mouse model. JCI Insight 3(1). pii: 92587 (https://doi.org/10.1172/jci.insight.92587)
- Kisalu N, Idris A, Weidle C, Flores-Garcia Y, Flynn B, Sack B, Murphy SC, Kappe S, Schön A, Freire E, Francica J, Miller A, Riera S, Kanekiyo M, Wheatley A, McDermott A, Farney SK, Chuang G, Zhang B, Natasha KC, Chakravarty S, Kwong P, Bhatia S, Sim BKL, Hoffman S, Zavala F, Pancera M, Seder R. 2018. A human monoclonal antibody prevents malaria infection and defines a site of vulnerability on Plasmodium falciparum circumsporozoite protein. Nature Med 24(4):408-416. (https://doi.org/10.1038/nm.4512)
- Foquet L, Schafer C, Minkah NK, Alanine DGW, Flannery EL, Steel RWJ, Camargo N, Fishbaugher M, Betz W, Nguyen T, Billman ZP, Wilson EM, Bial J, Murphy SC, Draper SJ, Mikolajczak SA, Kappe SHI. 2018. Plasmodium falciparum liver stage infection and transition to stable blood stage infection in liver-humanized and blood-humanized FRGN KO mice. Frontiers Immunol 9:524 (https://doi.org/10.3389/fimmu.2018.00524)
- Olsen TM, Stone BC, Chuenchob V, Murphy SC. 2018. Prime-and-trap malaria vaccination to generate protective CD8+ liver resident memory T cells. J Immunology. 201(7) 1984-1993. (https://doi.org/10.4049/jimmunol.1800740
- Highlighted in Journal of Immunology In This Issue (top 10% of all JI articles) - October 1, 2018, 201 (7) 1811-1812; DOI: https://doi.org/10.4049/jimmunol.1890016 (News coverage: UW)
- Shears M, Murphy SC. Vancomycin improves Plasmodium yoelii malaria parasite in vitro liver stage cultures by controlling Elizabethkingia anophelis, a bacterium in the microbiome of lab-reared Anopheles mosquitoes. Mol Biochem Parasitol 111279 (https://doi.org/10.1016/j.molbiopara.2020.111279). PMID: 32360511
- Goswami D, Betz W, Kamal N, Parthiban C, Brager C, Schäfer C, Camargo N, Nguyen T, Murphy SC, Vaughan A, Kappe S. 2020. A replication-competent late liver stage-attenuated human malaria parasite. JCI Insight 10.1172/jci.insight.135589.
- Goswami D, Betz W, Kamal N, Parthiban C, Brager C, Schäfer C, Camargo N, Nguyen T, Murphy SC, Vaughan A, Kappe S. 2020. A replication-competent late liver stage-attenuated human malaria parasite. JCI Insight https://doi.org/10.1172/jci.insight.135589
- Schäfer S, Roobsoong W, Kangwanrangsan N, Bardelli M, Rawlinson TA, Dambrauskas N, Trakhimets O, Parthiban C, Goswami D, Reynolds LM, Kennedy SY, Flannery EL, Murphy SC, Sather DN, Draper SJ, Sattabongkot J, Mikolajczak SA, Kappe SHI. 2020. A humanized mouse model for Plasmodium vivax to test interventions that block liver stage to blood stage transition and blood stage infection. iScience. 23(8):101381. https://doi.org/10.1016/j.isci.2020.101381. PMID: 32739836
- Shears MJ, Seilie AM, Sim BKL, Hoffman SL, Murphy SC. Quantification of Plasmodium knowlesi versus Plasmodium falciparum in the rhesus liver: implications for malaria vaccine studies in rhesus models. 19(1):313. https://doi.org/10.1186/s12936-020-03385-4. PMID: 32867784.
- Watson FN, Shears MJ, Matsubara J, Kalata AC, Seilie AM, Talavera IC, Olsen TM, Tsuji M, Chakravarty S, Sim BKL, Hoffman SL, Murphy SC. 2022. Cryopreserved sporozoites with and without the glycolipid adjuvant 7DW8-5 protect in prime-and-trap malaria vaccination. Am J Trop Med Hyg. PMID: 35226868 DOI: 10.4269/ajtmh.21-1084.
- Goswami D, Kumar S, Betz W, Armstrong JA, Haile MT, Camargo N, Parthiban C. Seilie AM, Murphy SC, Vaughan AM, Kappe S. 2022. A Plasmodium falciparum ATP binding cassette transporter is essential for liver stage entry into schizogony. iScience 8;25(5):104224. (https://doi.org/10.1016/j.isci.2022.104224): PMID: 35521513
- Wilder BK, Vigdorovich V, Carbonetti S, Minkah N, Hertoghs N, Raappana A, Cardamone H, Oliver BG, Trakhimets O, Kumar S, Dambrauskas N, Arredondo SA, Camargo N, Murphy SC, Kappe SHI, Sather DN. 2022. Anti-TRAP/SSP2 monoclonal antibodies can inhibit sporozoite infection and enhance protection of anti-CSP monoclonal antibodies. NPJ Vaccines. 7(1):58. (https://doi.org/10.1038/s41541-022-00480-2). PMID: 35618791
- Kimingi HW, Kinyua AW, Achieng NA, Wambui KM, Mwangi S, Nguti R, Kivisi CA, Jensen ATR, Bejon P, Kapulu MC, Abdi AI, Kinyanjui SM; CHMI-SIKA Study Team (including Murphy SC). 2022. Breadth of antibodies to Plasmodium falciparum variant surface antigens is associated with immunity in a controlled human malaria infection study. Front Immunol. 13:894770. (https://doi.org/10.3389/fimmu.2022.894770). PMID: 35711446.
- Zhu Y, Shen R, Vuong I, Reynolds RA, Shears MJ, Yao Z-C, Hu Y, Cho WJ, Kong J, Reddy SK, Murphy SC, Mao H-Q. 2022. Multi-step screening and composition optimization of lipid nanoparticles for prolonged liver-targeted DNA delivery. Nat Comm 13:4282. (https://doi.org/10.1038/s41467-022-31993-y).
- Chakravarty S, Shears MJ, James ER, Rai U, KC N, Murphy SC, Hoffman SL. 2022. Efficient infection of non-human primates with purified, cryopreserved Plasmodium knowlesi sporozoites. Malaria J (accepted 7/17/2022)
- Talley AK, Healy SA, Finney OC, Murphy SC, Kublin J, Salas CJ,, Lundebjerg S, Gilbert P, Whisler J, Van Voorhis WC, Wang R, Murphy JR, Ockenhouse CF, Heppner DG, Kappe SH, Duffy PE. 2014. Safety and comparability of controlled human Plasmodium falciparum infection by mosquito bite in malaria-naïve subjects at a new facility for sporozoite challenge. PLoS ONE 9(11): e109654. (https://doi.org/10.1371/journal.pone.0109654)
- Kublin JG, Mikolajczak SA, Sack BK, Fishbauger M, Seilie A, Shelton L, VonGoederdt T, Firat M, Magee S, Fritzen E, Betz W, Kain HS, Dankwa DA, Steel, RWJ, Vaughan AM, Sather DN, Murphy SC, Kappe SHI. 2017. Complete attenuation of a genetically-engineered Plasmodium falciparum parasite in humans. Sci Transl Med 9(371): (https://doi.org/10.1126/scitranslmed.aad9099)
- Murphy SC, Duke ER, Shipman KJ, Jensen RL, Fong Y, Ferguson S, Janes HE, Gillespie K, Seilie AM, Hanron AE, Rinn L, Fishbaugher M, VonGoedert T, Fritzen E, Kappe SH, Chang M, Sousa JC, Marcsisin SR, Chalon S, Duparc S, Kerr N, Möhrle JJ, Andenmatten N, Rueckle T, Kublin JG. 2018. A randomized trial of the prophylactic activity of DSM265 against pre-erythrocytic Plasmodium falciparum controlled human malaria infection by mosquito bites and direct venous inoculation. J Infect Dis 217(5):693-702. (https://doi.org/10.1093/infdis/jix613).
- Healy SA, Murphy SC, Hume JCC, Shelton L, Kuntz S, Van Voorhis WC, Moodie Z, Metch B, Wang R, Silver-Brace T, Fishbaugher M, Kennedy M, Finney OC, Chaturvedi R, Hobbs CV, Warner-Lubin M, Talley AK, Wong-Madden S, Stuart K, Wald A, Kappe SH, Kublin JG, Duffy PE. 2019. Chemoprophylaxis vaccination: Phase 1 study to explore stage-specific immunity to Plasmodium falciparum in U.S. adults. Clin Infect Dis ciz1010. (http://doi.org/10.1093/cid/ciz1010). PMID: 31621832.
- Wockner LF, Hoffmann I, Webb L, Mordmüller B, Murphy SC, Kublin JG, O'Rourke P, McCarthy JS, Marquart L. 2020. Growth Rate of Plasmodium falciparum: Analysis of Parasite Growth Data From Malaria Volunteer Infection Studies. J Infect Dis 221(6):963-972. (https://doi.org/10.1093/infdis/jiz557). PMID: 31679015.
- Kublin J, Murphy SC, Maenza J, Seilie AM, Jain JP, Goswami B, Berger D, Spera D, Stein DS, Zhao R, Hackling M, Soon RL, Czartoski JL, Potochnic MA, Duke E, Chang M, Vaughan A, Kappe SHI, Leong FJ, Pertel P. Prince WT. 2020. Safety, pharmacokinetics and causal prophylactic efficacy of KAF156 in a Plasmodium falciparum human infection study. Clin Infect Dis. ciaa952 (https://doi.org/10.1093/cid/ciaa952).
- Murphy SC, Deye GA, Sim BKL, Galbiati S, Kennedy JK, Cohen KW, Chakravarty S, KC N, Abebe Y, James ER, Kublin JG, Hoffman SL, Richie TL, Jackson LA. 2021. PfSPZ-CVac efficacy against malaria increases from 0% to 75% when administered in the absence of erythrocyte stage parasitemia: a randomized, placebo-controlled trial with controlled human malaria infection. PLoS Pathog. 17(5): e1009594. PMID: 34048504.
- Mwakingwe-Omari A, Healy SA, Lane J, Cook DM, Kalhori S, Wyatt C, Kolluri A, Marte-Salcedo O, Imeru A, Nason M, Ding LK, Decederfelt H, Duan J, Neal J, Raiten J, Lee G, Hume JCC< Jeon JE, Ikpeama I, KC N, Chakravarty S, Murshedkar T, Church LWP, Manoj A, Gunasekera A, Anderson C, Murphy SC, March S, Bhatia SN, James ER, Billingsley PF, Sim BKL, Richie TL, Zaidi I, Hoffman SL, Duffy PE. 2021. Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity. Nature. 595(7866):289-294. doi: 10.1038/s41586-021-03684-z. PMID: 34194041.
- Pal S, Myburgh J, Bansil P, Hann A, Robertson L, Gerth-Guyette E, Ambler G, Bizilj G, Kahn M, Zobrist S, Manis MR, Styke NA, Allan V, Ansbro R, Akingbade T, Bryan A, Murphy SC, Kublin JG, Layton M, Domingo GJ. 2021. Reference and point-of-care testing for G6PD deficiency: Blood disorder interference, contrived specimens, and fingerstick equivalence and precision. PLoS One 16(9):e0257560. doi: 10.1371/journal.pone.0257560. PMID: 34543346.
- Shaffer D, Kumwenda J, Chen H, Akelo V, Angira F, Kosgei J, Tonui R, Ssali F, McKhann A, Hogg E, Stewart VA, Murphy SC, Coombs R, Schooley R; A5297 Team. 2022. Brief Report: No Differences Between Lopinavir/ritonavir and non-Nucleoside Reverse Transcriptase Inhibitor-based Antiretroviral Therapy on Clearance of Plasmodium falciparum Subclinical Parasitemia in Adults Living With HIV Starting Treatment (A5297). J Acquir Immune Defic Syndr. 89(2):178-182. doi: 10.1097/QAI.0000000000002839. PMID: 34693933.
Malaria Parasite Biology & Pathogenesis
- Murphy SC, Breman JG. 2001. Gaps in the childhood malaria burden in Africa: cerebral malaria, neurological sequelae, anemia, respiratory distress, hypoglycemia and complications of pregnancy. Am J Trop Med Hyg. 64(Supp 1-2):57-67. (https://doi.org/10.4269/ajtmh.2001.64.57)
- Murphy SC, Samuel BU, Harrison T, Speicher KD, Speicher DW, Reid ME, Prohaska R, Low PS, Tanner MJ, Mohandas N, Haldar K. 2004. Erythrocyte detergent-resistant membrane proteins: their characterization and selective uptake during malarial infection. Blood. 103(5):1920-8. (https://doi.org/10.1182/blood-2003-09-3165)
- Murphy SC, Hiller NL, Harrison T, Lomasney JW, Mohandas N, Haldar K. 2006. Lipid rafts and malaria parasite infection of erythrocytes (review). Molecular Membrane Biology. 23(1):81-88. (https://doi.org/10.1080/09687860500473440)
- Murphy SC, Harrison T, Lomasney J, Hamm H, Mohandas N, Haldar K. 2006. Erythrocyte G protein as a novel target for malarial chemotherapy. PLoS Med. 3(12):e528. (https://doi.org/10.1371/journal.pmed.0030528)
- Murphy SC, Fernandez-Pol S, Chung PH, Murthy SNP, Milne SB, Salomao M, Brown HA, Lomasney JW, Narla M, Haldar K. 2007. Cytoplasmic remodeling of erythrocyte raft lipids during infection by the human malaria parasite Plasmodium falciparum. Blood. 110(6):2132-9. (https://doi.org/10.1182/blood-2007-04-083873)
- Marvin RG, Wolford JL, Kidd MJ, Murphy S, Ward J, Que EL, Mayer ML, Penner-Hahn JE, Haldar K, O'Halloran TV. 2012. Fluxes in "free" and total zinc are essential for progression of intraerythrocytic stages of Plasmodium falciparum. Chem Biol. 19(6):731-41. (https://doi.org/10.1016/j.chembiol.2012.04.013)
- Haldar K, Murphy SC, Milner DA, Taylor TE. 2007. Malaria: mechanisms of erythrocytic infection and pathological correlates of severe disease. Annual Review of Pathology: Mechanisms of Disease. 2: 217-49. (https://doi.org/10.1146/annurev.pathol.2.010506.091913)
Vaccines for Other Pathogens
- Fry LM, St all. 2019. Gene gun DNA immunization of cattle induces humoral and CD4 T-cell-mediated immune responses against the Theileria parva polymorphic immunodominant molecule. Vaccine 37(12):1546. (https://doi.org/10.1016/j.vaccine.2019.02.009)
Ethics and Global Health Policy Papers
- Murphy SC. 2006. Malaria and global infectious diseases: why should we care? Virtual Mentor. 8:245-250. (link)
- Kraft SA, Duenas D, Shipman KJ, Kublin JG, Murphy SC, Shah SK. 2018. Exploring ethical concerns about high payments for human infection challenge studies: A qualitative study of participants’ motivations, perceptions of risk and payment, and potential deception in a controlled human malaria infection study J Empir Res Hum Res Ethics 1556264618820219 (https://doi.org/10.1177/1556264618820219)
- Shah SK, Miller FG, Darton TC, Duenas D, Emerson C, Fernandez Lynch H, Jamrozik E, Jecker NS, Kamuya D, Kapulu M, Kimmelman J, MacKay D, Memoli MJ, Murphy SC, Palacios R, Richie TL, Roestenberg M, Saxena M, Saylor K, Selgelid MJ, Vaswani V, Rid A. 2020. Responding to the COVID-19 pandemic: Ethical considerations for conducting controlled human infection studies. 2020. Science. eabc1076 (https://doi.org/10.1126/science.abc1076). (and our response to letter by Nir et al. is at https://doi.org/10.1126/science.abc9380.
- Murphy SC, Duenas DM, Richie TL, Shah SK. 2020. Reexamining the categorical exclusion of pediatric participants from controlled human infection trials. Bioethics. 2020 Jul 26. https://doi.org/10.1111/bioe.12788. PMID: 32715497.