First author Yining Zhu, Dr. Hai-Quan Mao's Laboratory at Johns Hopkins, and the Murphy Laboratory at UW are happy to share that the first manuscript funded by our NIH U01 project to develop a liver-targeted, nanoparticle-based malaria vaccine is now online in Nature Communications (link: https://www.nature.com/articles/s41467-022-31993-y). This study sought to rationally build a liver-targeted, DNA plasmid-bearing nanoparticle for hepatocyte expression. This type of particle could potentially be used in liver-specific nucleic acid vaccination (work is underway with NIH funding), in gene therapy, and in other applications. Congrats to the entire team for this amazing work -- look for more coming soon!
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