We conducted a study with collaborators at Med Biotech in Uganda to assess the natural history of asymptomatic malaria in a malaria-endemic part of the country. The study relied on at-home, participant-collected dried blood spots (DBS) and cost-effective DBS pooling strategies and revealed a high rate of asymptomatic infections and the very dynamic nature of these infections. The study is now published in Lancet Microbe (Assessing the daily natural history of asymptomatic Plasmodium infections in adults and older children in Katakwi, Uganda: a longitudinal cohort study - https://www.sciencedirect.com/science/article/pii/S2666524723002628). More info about the study is also available on the UW Medicine News site (https://newsroom.uw.edu/news-releases/classifying-the-natural-history-of-asymptomatic-malaria). We are grateful to our partners at Med Biotech and to the volunteers for their generous participation in this important study. We hope to use the methods developed and lessons learned from this study to continue our work to understand these low-density infections as the world works toward the ambitious goal of malaria elimination.
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