(https://doi.org/10.1016/j.vaccine.2019.02.009)
A report from our ongoing collaboration with Washington State University and the USDA is now published in Vaccine. In this study, DNA encoding the Theileria parva polymorphic immunodominant molecule or 'PIM' was able to elicit antibody and T cell responses using just 5 micrograms of gene gun-delivered DNA per dose (in 1,000 lb animals!). Codon optimization of PIM-coding sequences enhance responses. Although we don't yet have an effective DNA vaccine for East Coast Fever, this study affirms the potent immunogenicity of gene gun-delivered DNA vaccines in large animals like cattle and helps guide us on where to go in the future. Thanks to collaborators Dr. Lindsay Fry, Dr. Don Knowles, and their teams for their partnership on this study.
(https://doi.org/10.1016/j.vaccine.2019.02.009) |
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